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O-Acetylpsilocin (also known as psilacetin, 4–acetoxy–DMT, or 4–AcO–DMT) is a semi-synthetic psychoactive drug by David Nichols to be a potentially useful alternative to psilocybin for pharmacological studies, as they are both believe to be prodrugs of psilocin.
4–AcO–DMT is unscheduled in the United States. It may be considered an analogue of psilocin, a Schedule I drug under the Controlled Substances Act, which means the sale for human consumption or the use for non-medical or research purposes, by itself, and with the right dosage, it is harmless. However, it interacts negatively with some substances like antidepressants, alcohol, xanax, tramadol and so on.
A 4-aco-DMT trip is relatively short, with the peak occurring just a few minutes after smoking, and the entire experience usually lasting less than 20 minutes. Still, depending on the dose, the actual experience may feel much longer, and some people report the effects of DMT lingering for up to an hour or two after the peak.
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Buy 4-AcO-DMT online. Dimethyltryptamine (DMT) is the most intense drug and also naturally-occurring psychedelic that’s also found endogenously in the human body. It’s not as popular as LSD or psilocybin, though its use has grown over time.
Concerning 4 aco dmt dosage there are, however, claims of subjective differences in effect between the acetylated and non-acetylated forms of psilocin. Some users report that it lasts slightly longer than psilocin while others report that it lasts for a considerably shorter.
Some users find that the visual distortions produced by it is more closely resemble those produced by DMT than those produced by psilocin. These differences could be possible if 4-AcO-DMT is active itself and not merely as a pro-drug.
4-ACO-DMT ‘s psychedelic effects are believe to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
The effects of 4-Aco-DMT are very similar to the effects of psilocybin/psilocin, although enough users have report some differences that it is speculated that 4-Aco-DMT may be uniquely active on its own, and not simply active due to being metabolized into psilocin.
Users report dose-dependent colorful visual effects and a sense of physical energy or euphoria, sometimes accompanied by abstract, associative, “trippy” thought patterns, or derealization.
Several available reports of 4-Acetoxy-DMT compare it favorably to psilocybin, describing it as more euphoric, gentle, warm, and colorful. It has also been describe as less jarring, and less likely to produce nausea. However, most of these comparisons are made with mushrooms, not pure psilocybin. In addition, it is unknown to what degree expectancy plays a role in shaping such experiences.
In the body, 4-AcO-DMT / psilacetin is thought to be deacetylated into psilocin during first pass metabolism and subsequent passes through the liver; evident as psilacetin is also active when injected.
This has not been formally proven, however, and is based on reports that most users cannot tell the difference between these two compounds when ingested to the point that they are often considered as indistinguishable from each other in terms of their subjective effects.
Buy 4-ACO-DMT Online, O-Acetylpsilocin is a synthetically produced psychoactive drug and has been suggested by David Nichols to be a potentially useful alternative to psilocybin for pharmacological studies, as they are both believed to be prodrugs of psilocin.
4-aco-dmt buy taste is unpleasant but the quantity consume is tiny and just drinking something after will get the taste out of your mouth. Really strong, sour, and disgusting.
4-ACO-DMT buy Online and several other psychedelic products such as lsd blotter pappers, mdma, ketamine and many other products. Despite this fact, 4-AcO-DMT remains a psychedelic with a limited history of use prior to its release. As a grey area compound on the online research chemical market.
4-Acetoxy-N,N-dimethyltryptamine ( psilacetin, 4-Acetoxy-DMT , and O-Acetylpsilocin) is a novel psychedelic substance of the tryptamine class. It is chemically similar to psilocybin, the active ingredient in psilocybin mushrooms (magic mushrooms). It belongs to a group known as the substituted tryptamines which act by stimulating serotonin receptors in the brain.
Obviously the question of 4-AcO-DMT legal will depend on where you live. However, you may be in for a surprise if you expect it to be just like psilocybin. Although many find it comparable, it’s often describe as being more like DMT.
O-Acetylpsilocin 4-Acetoxy-DMT synthetically produce psychedelic tryptamine. It is the acetylated form of the psilocybin mushroom alkaloid psilocin. And is a lower homolog of 4-AcO-DET, 4-AcO-MiPT, and 4-AcO-DiPT.
Pharmacological studies shows they are products of psilocin. Its structural similarities to psilocin and psilocybin results in an identical subjective effect profile. These three compounds are indistinguishable from each other. This allows 4-AcO-DMT to function as a perfect substitute for psilocybin mushrooms. Buy 4-ACO-DMT Online here
It’s also worth noting that the precise concentration of your 4-AcO-DMT powder will depend. On whether it’s in the form of a fumarate or hydrochloride (HCl) salt. Every 1.24 mg fumarate, for example, is expect to contain 1 mg 4-AcO-DMT. While the equivalent amount in HCl would be 1.15 mg for 1 mg 4-AcO-DMT.
Buy 4 aco dmt (or psilacetin) is a semi-synthetic tryptamine closely related to the “magic mushroom” molecules psilocin and psilocybin. Like psilocybin, it appears to be metabolized by the body into psilocin. Most people buy psilacetin as a brown or off-white powder that can be mixed with water just before dosing. But it’s also available in pills, tablets, capsules, and gel tabs among other preparations. While some find the effects indistinguishable from psilocybin mushrooms, others say it’s more like DMT. The difference may be dose-dependent. But mystical-type experiences are common, as are philosophical insights and a sense of empathic well-being.
Among the most common effects of 4-AcO-DMT are spiritual or mystical experiences and compassion for the people in one’s life. Openness with family is a recurring theme. One person found the softening of his ego allowed him to have a long-overdue conversation with his brother about their mother’s death. Finally telling him things that he “should have said much earlier”. He was also able to reconnect and “productively engage” with his father. Another felt similarly empowered, coming to understand the “problematic tension” between himself and his father and resolving “to mend their fractured state.”
Gratitude, acceptance, trust, and letting go are some other common themes. As one psychonaut put it, “whereas mushrooms operate in a part of the brain that could be considered about language or intellect, 4-AcO-DMT acts on the emotional thought processes” . By taking 4-AcO-DMT once every couple of months, he said, he was better able to manage his “warped” emotions.
As a more stable prodrug of psilocin than psilocybin, and one that’s more easily synthesized. 4-AcO-DMT may be useful for clinical research. It was used, for example, to test the hypothesis that 5-HT2A agonists can alleviate withdrawal symptoms and even prevent addictions from forming. Opiate-dependent rodents given 4-AcO-DMT were effectively cured of their addiction. And a single dose of 4-AcO-DMT given before chronic nicotine exposure blocked their transition to a nicotine-dependent state. How 4-AcO-DMT may be used to treat addiction in humans remains to be seen, but these results support neurobiological theories of dependence—and in particular, the hypothesis that serotonergic agents can be used to regulate underlying mechanisms involving GABA (gamma-aminobutyric acid) receptors and BDNF (brain-derived neurotrophic factor) in the ventral tegmental area of the brain.
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The authors of this study also suggested that 4-AcO-DMT might be useful for the treatment of depression via the same pathway and the regulation of “aberrant glutamatergic activity”. 5-HT2A agonists could offer substantially longer-lasting relief than drugs regulating glutamatergic activity via different pathways, such as the NMDA (N-methyl-D-aspartate) antagonist ketamine. Anecdotal reports appear to lend further support. Whereas prescribed antidepressants can have a “numbing” effect, for instance, 4-AcO-DMT is said to help resolve underlying “emotional damage” . One man was able to overcome his PTSD through just six trips, describing the compound as “life-changing” and likening his experiences with it to “unknotting scar tissue” and rediscovering his “inner confident self”. Another self-medicator, a victim of childhood abuse, said she was able to work through her trauma with 4-AcO-DMT . She also move on with her life in a way that prescribed medications actively seemed to prevent.
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And yet another, frustrated with conventional antidepressants, credited 4-AcO-DMT with allowing him to “experience happiness and connection,” . While also decreasing his reliance on alcohol. This has seen some argue that the drug is not harmful and should be made legal, but this remains a situation to see.